Chapter 5 Section 4: Proteins and their cellular locations, after p. 185:
Topic Name: Protein Morpher at the University of Massachusetts
In the upper left hand corner is a stereoscopic view of the 3-dimensional structure of the protein recoverin. Many proteins change their shape, or conformation, in response to different conditions. An enzyme changes shape when it binds to its substrate. A cell surface receptor (EGF receptor) changes conformation when it binds a growth factor (EGF). Myosin changes its conformation when it binds actin to cause muscle contraction. Conformational change in protein structure is a recurring theme in biological systems and you will see this concept again (cell signaling).
Recoverin is a protein that is found in the retina and in part of the brain. It binds to calcium, and when it does it changes conformation. Researchers propose that this conformational change may look something like the model in this web site.
Which level(s) of protein structure changes when recoverin undergoes this conformational change?
Which levels of protein structure do not change?